Strains of MRSA (methicilin resistant Staphylococcus aureus) express cell surface hydrophobicity just as the non-resistant bacteria do and therefore also bind to Cutimed Sorbact. The same applies to VRE (vancomycin resistant Enterococcus).

The Sorbact method is based on hydrophobic interaction. This basic physical principle is vital for microorganisms, e.g. for intake of food, exchange of genetic information, or adherence to tissue cells in the infective process. Development of resistance against hydrophobic interaction would be self-destructive for microorganisms.