Which kind of microorganisms bind to Cutimed Sorbact?
Can microorganisms overcome the binding to Cutimed Sorbact?
Can the microorganisms continue to grow when bound to Cutimed Sorbact?
Does the microbial binding of Cutimed Sorbact reach a saturation point?
What about microorganisms located in the pus or debris of the wound?
How long does it take the microorganisms to bind to the dressings?
Cutimed Sorbact is effective against all common wound pathogens: gram positive (e.g. Staphylococcus, Streptococcus, Clostridium) and gram negative bacteria (e.g. Pseudomonas, E. coli, Enterobacter) as well as fungi (e.g. Candida albicans) [Ljungh, Wadström; Microbiol. Immunol. 39 (10), 1995, 753-57].
This includes antibiotic resistant bacteria like MRSA or VRE as their resistance does not change their binding to Cutimed Sorbact.
No, the binding is irreversible in a moist wound environment.
No, bound microorganisms are inactivated and do not replicate. When bound to a surface it is the microorganisms' natural behaviour to slow down their metabolism. Consequently, the formation and emission of bacterial toxins are also slowed down or stopped.
A saturation point was not reached in an in-vitro investigation by Ljungh et al. [JWC 15 (4), 2006, 175-80]. A binding capacity of up to one hundred million bacteria per square cm dressing was determined. This number exceeds the bacterial load that you would find in an infected wound.
Debris and pus also have hydrophobic properties and bind to Cutimed Sorbact as well as the microorganisms.
An in-vitro test by Ljungh et al. [JWC 15 (4), 2006, 175-80] showed that binding takes place rapidly, i.e. within 30 seconds. When measured after 2 hours, Cutimed Sorbact continuously bound more microorganisms.
